Mycinop
Dosage Form : Water soluble powder
Composition :
Each 100gm contains:
Neomycin Sulphate ……………………………………………………………………………70 gm
(Equivalent to Neomycin base 49 gm)
Properties:
Neomycin, the drug’s active substance, is aminoglycoside class antibiotic characterized by bactericidal action against most gram- negative pathogens: E. coli sp., Salmonella sp., Proteus sp., Haemophilus sp., Klebsiella sp. Shigella sp., Pasteurella sp., and gram- positive: Staphylococcus sp., Streptococcus sp., Corynebacterium sp.
Neomycin is poorly absorbed from digestive tract. It remains fully active in stomach and intestines, despite presence of food, pus, necrotic tissues and changing pH value. Approximately 97% of applied dose is eliminated from organism with faeces matter. Neomycin’s bactericidal action results from bacterial protein synthesis inhibition at ribosomal level. Immunity to neomycin is formed very slowly – in bacterial populations mutants resistant to the drug are rare
Indications:
Broiler Chickens:
Mycinopi : used for treatment of diarrhea associated with salmonellosis that caused by Salmonella spp.
Mycinopi: reduce mortalities associated with Colibacillosis caused by Escherichia coli and the diarrhea caused by any of the susceptible organisms that mentioned above.
Target species
Dosage& Route of administration
Warning &Precaution:
Contraindication :
Side Effects
Withdrawal time
Storage
Packs:
Target species
Broiler ChickensDosage& Route of administration
Route of administration: Orally. Broiler Chickens For active ingredient: 11 mg neomycin sulfate / kg. body weight For whole product: 55 gm of product/3500 kg.b.wt ( 0.5-1gm/3.5 liter ) drinking water , daily for 3-5 daysWarning &Precaution:
- Administer in a good quantity of water to consume the dose completely.
- Prepare the medicated water daily.
- Do not administer with neuromuscular blockers, general anesthetics, anti diuretics or other aminoglycosides.
Contraindication :
*Do not administer to dehydrated animals, with kidney failure or respiratory depression. Do not administer to animals with history of hypersensitivity to the antibiotic.* *Prolonged use may cause bad absorption syndrome and intestinal dysbacteriosis. *At high doses and for long periods it can cause nephrotoxic and ototoxic effectsSide Effects
- The prolonged use can cause malabsorption syndrome & intestinal dysbacteriosis.
- At high dose and prolonged use can cause nephrotoxic and ototoxic effect.
- Aminoglycosides may impair neuromuscular transmission if used peri-operatively in association with anesthesia.
