Opi-Arthridine

Dosage Form :Injection

Each  ml contains :

Phenylbutazone                         200 mg

Sodium salicylate                        20 mg

Pharmacological action :

Phenylbutazone is non-steroidal anti-inflammatory, analgesic and antipyretic agent .

Sodium salicylate is a salicylic acid derivative that has analgesic, anti-inflammatory and antipyretic actions similar to those of aspirin .

Both has synergic effect and they inhibit cyclo-oxygenase, (prostaglandin synthetase) thereby reducing the synthesis of prostaglandins .

Sodium salicylate antagonize  the gastrointestinal ulcerogenic effect of phenylbutazone .

Indications :

Anti-inflammatory  treatment of the musculoskeletal affections (arthritis, luxation, tendenitis)

Inflammatory complications of various traumatic and  microbial affections .

Aid in treatment of acute pneumopathy .

Treatment of lameness in horses .

It is used as an analgesic/anti-inflammatory, antipyrexic in horses.

Category:
Contraindications
Side effect
Drug interaction
Warnings
Dosage & administrations
Storage
Withdrawal time
Package

Contraindications

Horses with cardiac, renal or hepatic diseases where there is a possibility of gastrointestinal  ulceration or bleeding . Hypersensitivity to the drug or treatment with other NSAID . Race horses prior to racing and Pregnant mares . concurrent administration with aminoglycosides  . Animals less than 30 days of age, less than 7 days before surgery .

Side effect

Prolonged use may cause gastrointestinal lesions, inappetance, vomiting and diarrhea .

Drug interaction

phenylbutazone is highly bound to plasma proteins and may displace other highly bound drugs like phenytoin, valproic acid, sulphonamides and other anti-inflammatory agents .

Warnings

Caution with use in animals less than 6 weeks of age or aged  animals . Avoid use in dehydrated, hypovolaemic or hypertensive patients . Avoid concurrent administration  of potentially nephrotoxic  drugs . Stop medication at the first sign of gastrointestinal upset , jaundice or blood discrasia. In the treatment of inflammatory conditions associated with infections, specific anti-infective therapy is required  .

Dosage & administrations

Slow intravenous injection . Horses & foals Intially 5 – 10 ml per 225 kg per day Subsequent doses, depending on response, may be reduced to 2.2 – 5 ml per 225 kg per day. Treatment should be continued for 5 – 6 days

Storage

Store between 2 - 8° C (Refrigerate. Don’t freeze). Protect from light.

Withdrawal time

Not to be used in horses intended for human consumption.

Package

Amber color glass vials of 10, 20, 25, 30, 50, 100 and 250 ml. in carton box                                                                                                                                               with pamphlet.

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